The interactome of the A2A adenosine receptor in vitro and in vivo
نویسندگان
چکیده
Background The A2A adenosine receptor is a prototypical G proteincoupled receptor. It is expressed in a wide variety of cells including as different types as neurons, platelets, cells of the immune system and muscle. The cell-specific expression of the A2A adenosine receptor is controlled by at least three different upstream non-coding exons and their corresponding promotors. Compared to other G protein-coupled receptors the A2A receptor holds an unusually long intracellular carboxy terminus, which consists of 122 amino acids. This C-terminus turned out to be the docking site for other proteins. Using a yeast-2hybrid screen we have previously identified proteins interacting with the C-terminus including ARNO/cytohesin-2, SAP102 and USP4.
منابع مشابه
Thymoquinone, the main constituent of Nigella sativa, affects adenosine receptors in asthmatic guinea pigs
Objective(s): For determining the mechanism of anti-asthmatic effect of thymoquinone, this investigation evaluated the effect of thymoquinone in the presence of selective A2A and A2B adenosine receptor antagonists (ZM241385 and MRS1706, respectively). Materials and Methods: Seventy guinea pigs were randomly divided to 7 groups; control (C), sensitized with ovalbumin (S), sensitized groups pretr...
متن کاملEffects of adenosine A2a receptor agonist and antagonist on cere-bellar nuclear factor-kBexpression preceded by MDMA toxicity
Background :Adenosine is an endogenous purine nucleoside that has a neuromodulatory role in the central nervous system. The amphetamine derivative (±)-3,4-methylenedioxymethamphetamine (MDMA or ecstasy) is a synthetic amphetamine analogue used recreationally to obtain an enhanced affiliated emotional response. MDMA is a potent monoaminergic neurotoxin with the potential of damage to brain neu...
متن کاملP138: Are Depression and Anxiety Affected by Adenosine A2A Receptors?
Adenosine acts as neuromodulator in the brain, which its involvement in a wide range of brain processes and diseases has been studied, such as epilepsy, sleep, anxiety, panic disorder, Alzheimer’s disease, Parkinson’s disease and schizophrenia. Adenosine receptors have been detected: A1R, A2AR (A2AR), A2BR, and A3R. A1R and A2R inhibit cAMP production, while A2AR and A2BR stimulate cAMP product...
متن کاملThe Role of Agonist of A2a Adenosine Receptors on Neurotoxicity of Mdma (Ecstasy Pill) on Rat’S Hippocampus
Purpose: MDMA is a synthetic drug that is originated from Amphetamine. It is used by some people. This material induces some chemical changes in serotonergic and dopaminergic neurons in middle brain. Materials and Methods: In this study, we used 49 Rats Sprague-Dawley, 200-250 gr. There were 7 groups and 7 Rats in each group. Rats received MDMA in the first group, in the second group CGS (A2A r...
متن کاملCEREBRAL BLOOD FLOW REGULATION IN ANESTHETIZED MORPHINE DEPENDENT RATS: THE ROLE OF THE ADENOSINE SYSTEM
Adenosine has many of the characteristics of a regulator of cerebral blood flow and adenosine receptors change in morphine dependency. In this study the changes in adenosine receptors' responsiveness of pial vessels in the hind limb area of the sensory cortex were evaluated in morphine dependent rats (MDR) using the laser Doppler flowmetry technique. Adult male Sprague Dawley rats (250-350 ...
متن کامل